Endocrine-Related Tumors

The tumorigenesis of sporadic endocrine tumors is silent not fully understood. Activating point mutations of the serine/threonine kinase gene BRAF (human gene that encodes a protein) located on 7q34 are originate in a comprehensive range of malignancies, with the highest frequency (66%) occurring in malignant melanomas. Melanomas are tumors of neural-crest-derived cells as are medullary thyroid carcinomas, pheochromocytomas and paragangliomas. BRAF has not been scanned in endocrine tumours of the diffuse neuroendocrine system or of neural-crest-derived cells. Cancers in endocrine organs —such as prostate, breast, pituitary, ovaries, testes.


  • Pheochromocytomas
  • Paragangliomas
  • Tumorigenesis
  • Thyroid carcinomas
  • Neural-crest-derived cells

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