Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend 25th International Conference on Human Metabolic Health- Diabetes, Obesity & Metabolism Carlton Palace Hotel | Dubai | UAE.

Day 1 :

Keynote Forum

Mahabaleshwar Hegde

Bharati Vidyapeeth University, India

Keynote: Distorted fatty acid metabolism and metabolic syndrome

Time : 08:30-09:30

Human Metabolism 2019  International Conference Keynote Speaker Mahabaleshwar Hegde photo
Biography:

Mahableshwar Hegde, PhD in biochemistry, has over 30 years post garduate teaching experience, guiding M.Sc, M.Phil, PhD students at Pune University and for the last 20 years has passionately working for omega-3 nutritional security, by establishing a “Center for Innovation in Nutrition Health and Disease (CINHD)” and “Real World Nutrition Laboratory Foundation (RWNLF)” in Bharati Vidyapeeth (deemed to be)University Pune, to validate the innovative omega-3 enriched products throgh FLAX BIOVILLAGE” concept devloped by him. He has published extensively and edited a book “OMEGA 3 FATTY ACID” keys to nutritional health, published by Springer International.

Abstract:

Metabolic syndrome, is a collection of risk factors that increases the chances of developing excessive body fat, heart disease, stroke and diabetes and it is primarily the result of recent abrupt dietary life style changes, more particularly distorted fatty acid intake. Our prehistoric food consisted of 1:1 ratio of omega-6 to omega-3 fatty acid. But today our diet has skewed ratio of 20-40:1. Both linoleic acid omega-6 and alphalinolenic acid omega-3 fatty acids are essential fatty acids. Excessive omega-6 and paucity of omega-3 fatty acid is almost a global phenomenon. Th is has led to the dominance of infl ammatory pathway in modern man and is primarily responsible in phenomenal increase in incidences and severity of chronic degenerative diseases. Omega-3 nutritional security and lowering of intake omega-6 fatty acid, correcting the imbalance is urgent need of the day. Th erefore, our goal has been to bring back primary essential omega-3 fatty acid, alphalinolenic acid, into the food chain. Flax seed is the richest source of vegetarian, omega-3 fatty acid. We have developed technogies, to increase production and productivity of fl axseed; to extract omega-3 oil and soft gel capsules from fl axseed devoid of antinutrients; to stabilize omega-3 fatty acid in emulsion to fortify milk and milk products; omega-3 enriched poultry feed mix for the production omega-3 enriched egg and chicken meat; omega-3 fl our mix for bakery products etc. Our pioneering eff orts, through well researched and validated “FLAX BIO_VILLAGE” concept, aims at attaining omega-3 nutritional security and correct the omega-6: omega-3 imbalance, to eff ectively tackle metabolic syndrome.

 

Human Metabolism 2019  International Conference Keynote Speaker Bandar Manawer Al Harbi photo
Biography:

Bandar Manawer Al Harbi is working as Assistant Director of Pharmacy for Material Management at Prince Sultan Military Medical City. His current research is in diabetes at DMU University, UK. He is an Adjunct Clinical Assistant Professor at King Saud University, College of Pharmacy and Director of Pharmacy and Director of Central Sterile Supplies Department, PSMMC, Director of Medical Supplies and Purchasing, PSMMC. He is the Chairman of the fi rst International Sterilization Symposium, Instructor of Purchasing Material Management/CSSD course. He is the active Member of American Society of Health System Pharmacist (ASHP) and Saudi Commission for Health Care Specialties. He has participated in many conferences globally

Abstract:

Introduction & Aim: Pre-diabetes describes a condition whereby an individual’s level of blood glucose is above normal level, though not high enough to warrant them a T2D diagnosis. Th e condition is classifi ed into two categories, Impaired Glucose Tolerance (IGT) where blood glucose levels are above the normal 2 hours aft er glucose loading in the oral glucose tolerance test but not so high to warrant the classifi cation as diabetes. Th e other is Impaired Fasting Glucose (IFG) where blood glucose have risen to a fasting state but yet again, not so high to warrant the classifi cation as diabetes. Physical exercise improves BG homeostasis but the extent to which exercise is eff ective strategy as primary prevention mechanism for people whom at risk to develop diabetes is not fully understood. Th e study aims to examine the eff ects of 6-weekes moderate-intensity combined aerobic and resistance exercise program in preventing or delaying the onset of diabetes for subjects at risk compared to sedentary non-diabetic individuals. Method: 20 subjects of a sedentary lifestyle, diagnosed with either pre-diabetes or at risk to developed T2D (PRE-D) and 5 subjects were sedentary healthy individuals (ND) met the inclusion criteria. Both PRE-D and ND have been asked to complete 6-weeks of moderate-intensity combined aerobic and resistance exercise for 60 minutes on two days/week. Each exercise session consists of a combined exercise protocol of 30 minutes of resistance exercise (3 sets of 10 repetitions) followed by 20 minutes cycling. Th e primary outcome is to concentrate on metabolic results, such as improved HbA1c, blood pressure, heart rate, 1-repition max, lipid profi le (reduction in total cholesterol, low density lipoproteins, triglycerides or increase high density lipoproteins) and improvements in insulin sensitivity determined by responses to oral glucose tolerance tests on independent days. Result: Th ere were signifi cant reduction (p=0.00) on the HbA1c aft er applying of 6 weeks’ combination exercise intervention in both groups comparing to baseline. OGTT indicated signifi cant diff erences between pre-exercise and post 12th exercise session in both groups with p=0.01. BG concentrations.

Keynote Forum

Najmul Islam

Aligarh Muslim University, India

Keynote: Allicin from garlic having beneficial effects in combating diseases

Time : 10:45-11:15

Human Metabolism 2019  International Conference Keynote Speaker Najmul Islam photo
Biography:

Najmul Islam is currently working as a Professor in Biochemistry, Faculty of Medicine, Aligarh Muslim University, India. He was the Former Head of the Department of Biochemistry. He has worked for four years in the Division of Infectious Diseases and Department of Rheumatology, Case Eastern Reserve University, Cleveland, Ohio, USA. He was Joint Secretary in 2012-13, Vice President, 2014 and President, 2015 of Indian Academy of Biomedical Sciences, Lucknow. He has published more than 70 papers/articles in reputed journals and has been serving as an Editorial Board Member of repute.

Abstract:

Introduction & Aim: Th e relationship between Reactive Oxygen Species (ROS) and various diseases like metabolic cardiac disorders, osteoporosis, tuberculosis and cancer and are well documented. Th e present study involves the employment of a natural compound namely allicin from garlic having anti-oxidant and anti-infl ammatory properties with proven health benefi ts. Our preliminary observations appear to possibly provide some scientifi c input that may be useful in the management of Ischemic Heart Disease (IHD), osteoporosis, tuberculosis and cancer. Method: Peripheral Blood Mononuclear Cells (PBMC’s) were isolated by density gradient method from blood of patients with Ischemic Heart Disease (IHD), osteoporosis, tuberculosis and cancer (n=20 each) and were employed in culture studies with and without of varying does of allicin (0-500 ng/ml). Th e 24 hr cultures were probed for CK, sTNF-alpha, sRANKL levels as well as for Glutathione Peroxidase (GPx) activity. Result: Cells were collected aft er 24 hours with and without allicin (0-500 ng/ml; n=20 each). An appreciably suppressed GPx activity was recorded in cell cultures of patient’s with IHD, osteoporosis, tuberculosis and cancer when compared to samples of healthy controls where the GPx data refl ects upon the compromised defense system in patients with Ischemic Heart Disease (IHD). On the contrary, treatment or co-culturing with varying doses of allicin (0-500 ng/ml) exhibited a remarkable degree of amelioration in GPx activity in cells of all the above four types of diseased patients. Next, the ELISA data showed that the 24 hr culture supernatants of untreated patients cells were having augmented expressions of sTNF-alpha, which upon co-culturing with 500 ng/ml of allicin resulted in an appreciable degree of downregulation/suppression in the expressions of sTNF-alpha in cells of all the above four types of diseased patients. Cultures from all patient types exhibited a dose dependent suppression with allicin. Similarly, in IHD patients, in comparison to untreated controls, a dose dependent decrease in CK levels were observed in cultures receiving allicin (0-500 ng/ml; n=10). Also, in cell cultures from osteoporosis patients, allicin (0-500 ng/ ml), showed an appreciable degree of downregulation in sRANKL. Conclusion: Th e encouraging preliminary data suggested that in-depth studies are required at the molecular level, which in turn, may provide information for possibly employing allicin as potential adjunct in the management of Ischemic Heart Disease (IHD), osteoporosis, tuberculosis and cancer. repute.

Keynote Forum

Nicolas Wiernsperger

Association REMEDES, France

Keynote: Anti-obesity potential of aged garlic extract: Overview
Human Metabolism 2019  International Conference Keynote Speaker Nicolas Wiernsperger photo
Biography:

Nicolas Wiernsperger is a Physiologist and has completed his PhD in Neurophysiology from University Basel, Switzerland. He has worked as the Head of Department of Brain Microcirculation at Novartis and also he was the Head of International Pharmacological Development at Lipha/Merck KgA in Lyon. He was also Head of a Private/ Public Research Unit on Diabetic Micro vascular Complications at Lyon University. He has been an Author/Co-author of about 150 publications and 2 scientifi c books. He has also worked as a Visiting Professor at several universities. He is presently a Private Consultant for Pathophysiological and Pharmacological aspects of cardio metabolic diseases.

Abstract:

Obesity is a hallmark of pre-diabetes with a conversion rate of close to 10%. However, recent large-scale clinical observations tell us that non-diabetic obesity (metabolic syndrome) is as dangerous as established diabetes for macro angiopathy. Obesity is becoming a huge worldwide health problem and actual lifestyle measures are of limited effi cacy, in addition to be diffi cult to sustain. Th erefore, complementary dietary measures are highly suitable. Among these, garlic and more particularly aged (black) garlic, is of particular potential interest based on its pharmacological properties which target most of the individual parameters causally involved in obesity development. Although a lot has still to be learned and precised about ideal composition and dosage for humans, animal research shows promising benefi cial eff ects. A recent trial with concentrated aged garlic extract has demonstrated impressive loss of weight over short treatment duration in high fat/high sucrose chronic fed rats. Several mechanisms, including central eff ects in hypothalamus, have emerged.