Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend 25th International Conference on Human Metabolic Health- Diabetes, Obesity & Metabolism Carlton Palace Hotel | Dubai | UAE.

Day 2 :

Human Metabolism 2019  International Conference Keynote Speaker Moinuddin photo
Biography:

Moinuddin has completed his MPhil and PhD in Biochemistry from the Faculty of Medicine of the Aligarh Muslim University, India. His research interest includes nucleic acid immunology, autoimmunity and free radical biology. He has published over 90 papers in reputed international journals, Seminars In Cancer Biology, FEBS Letters, ABB, BBRC, Rheumatology, PLoS One, IUBMB Life, etc. He is the recipient of Commonwealth Academic Fellowship to work in UK. He is a Life Member of Society for Free Radical Research (SFRR) and Indian Academy of Biomedical Sciences (IABS).

Abstract:

Structural rearrangements and condensations of proteins under glycoxidative stress have been implicated in various pathological disorders. Novel immunological epitopes upon glycoxidatively modifi ed proteins have been discovered and multi-specifi c natural antibodies against them have been identifi ed. In this study, we have probed the glycoxidation of Human Serum Albumin (HSA) and human IgG in diabetes type-2. Glycoxidation was found to perturb the structural integrity of HSA and IgG. It aff ected their aromatic micro-environment and caused the generation of Advanced Glycation End products (AGEs) and aggregate adducts. Generation of N-epsilon-Carboxy Methyl Lysine (CML) was observed under HPLC and LCMS studies. Th e modifi ed proteins showed altered secondary and tertiary structure that would also aff ect their function. Glycoxidation caused disordered or amorphous type aggregation in the modifi ed proteins, as confi rmed by electron microscopy. It enhanced carbonyl content and reduced the free lysine and arginine content. Modifi ed HSA and IgG presented novel antigenic determinants that lead to an aggressive immune response in the immunized rabbits as was evaluated by ELISA studies. Th e antibodies had high affi nity towards the immunogens. Auto-antibodies derived from T2DM patients exhibited strong affi nity towards the modifi ed HSA and IgG in comparison to the respective unmodifi ed proteins. Specifi city of serum antibodies from T2DM patients was further confi rmed by competitive-inhibition ELISA and gel retardation assays. Th e study shows that the neo-antigenic determinants on glycoxidatively modifi ed proteins generate specifi c immune response in diabetes type-2, which may possibly lead to the biomarker development for the disease.

Keynote Forum

Bulbin Jose

Latifa Hospital, UAE

Keynote: Nutrition management in bariatric surgery
Human Metabolism 2019  International Conference Keynote Speaker Bulbin Jose photo
Biography:

Bulbin Jose is a Registered Dietitian and is currently pursuing her PhD in Food Science and Nutrition from Bharathiar University Coimbatore, India. She has completed her MPhil degree in Food Science and Nutrition from Mother Theresa Women’s University, Kodaikkanal India in 2008. She has pursued her Master Degree in Food Science and Nutrition from Bharathiar University in 2003 and Bachelor Degree in Clinical Nutrition and Dietetics from M.G University, Kottayam, Kerala, India. She has completed her Food Safety Certifi cation course from IGNOU, New Delhi India and she cleared UGC-NET Exam in 2010. She has 15 years working experience as a clinical dietitian and lecturer in various multi super specialty hospitals in various countries. Currently she is working as Senior Clinical Dietitian in Dubai Health Authority. She has published several research papers in scientifi c peer reviewed international journals and she is speaker for various conferences.

Abstract:

Bariatric surgery is the most eff ective treatment method to help people with morbid obesity to lose weight and manage their health and weight. Bariatric surgeries can be divided into three categories such as restrictive procedures, malabsorptive procedures and combination (restrictive and malabsorption) procedures. Generally, patients undergoing restrictive procedures have the least risk for long-term diet-related complications, whereas patients undergoing malabsorptive procedures have the highest risk. In many patients, the benefi ts of weight loss, such as decreased blood glucose, lipids and blood pressure and increased mobility, will outweigh the risks of surgical complications. Most diet-related surgical complications can be prevented by following a strict eating behavior guidelines and supplement prescriptions. Eating behavior guidelines include restricting portion sizes, chewing foods slowly and completely, eating and drinking separately and avoiding foods that are poorly tolerated. Supplement prescriptions vary among practitioners and usually involve at least a multivitamin with minerals. Some practitioners may add other supplements only as needed for diagnosed defi ciencies; others may prescribe additional prophylactic supplements. Th e most common nutrient defi ciencies are defi ciency of iron, foliate and vitamin B12. Fat-soluble vitamins such as vitamin A, D, E and K have been reported in patients with malabsorption procedures and Th iamine defi ciency is very common among patients with inadequate food intake and/or nausea and vomiting. Th e diet aft er bariatric surgery is diff erent from all other diets. So plan the menu based on the nutrient requirements and adhere to that to lead a healthy post bariatric surgery life. Frequent monitoring of nutrition status for all patients undergone bariatric surgeries can be helpful in preventing severe clinical defi ciencies.

Human Metabolism 2019  International Conference Keynote Speaker Khurshid Alam photo
Biography:

Khurshid Alam completed his PhD in 1993 from Aligarh Muslim University College of Medicine. He became Faculty in the same year and teaching to undergraduate, postgraduate and doctoral students since then. He has already supervised 10 PhD and 05 MD and successfully operated 06 research projects. He has published more than 80 papers in journals of international repute.

Abstract:

Background & Aim: Naturally occurring proteins are signifi cantly more immunogenic than oligosaccharides and polysaccharides. Th e study of modifi ed-human IgG antigenicity is of particular interest due to the involvement of anti-IgG antibodies in the immunopathology of Rheumatoid Arthritis (RA). Human IgG show immunological behavior in its native conformation but glycation by ribose/deoxyribose/glucose/fructose/glyoxal/methylglyoxal etc. causes structural changes in the IgG and immunogenicity enhancement. In poorly controlled diabetes mellitus and in hyperglycaemia methylglyoxal formation is accelerated. In that scenario IgG being rich in lysine can be a soft target of heavy glycation by methylglyoxal/glucose duo. Th e glycation may progress to Amadori stage culminate into Advanced Glycation End products (AGE) and may further result in aggregate formation. Th e study aims to evaluate whether diabetic animals injected with IgG-methylglyoxal-glucose complex would elicit antibodies against the complex and also show increase in biochemical markers typical of RA. Th e sera of diabetes mellitus patients of diff erent age and disease duration will also be analyzed for auto antibodies against IgG-methylglyoxalglucose complex and markers of RA. Method: Experimental diabetes would be induced into rabbits by alloxan. Next, the diabetic rabbits will be injected weekly for seven weeks with IgG-methyglyoxal-glucose complex. Th e induction of antibodies and its specifi city would be evaluated by direct binding and specifi city enzyme immunoassay, respectively. Rheumatoid Factor (RF), TNF-α, IL-1 and 6 and CRP level will be estimated in the rabbit sera as well as in the sera diabetic patients of diff erent age and disease duration. Result: Diabetic animals challenged with IgG-methylglyoxal-glucose complex induced high titer antibodies having excellent specifi city towards the immunogens. Th e level of RF, TNF-α, IL-1 and 6 and CRP in immunogens injected diabetic sera was above respective cut-off values and signifi cantly more as compared to values in the sera of healthy or diabetic rabbits. Furthermore, auto antibodies in sera of diabetic patients showed enhanced binding with IgG-methylglyoxal-glucose complex. In a signifi cant number of cases, but not all that were included in this study, there was direct correlation between level of serum autoantibodies and age of the patients and duration of diabetes mellitus. Another important observation made during the study was that the sera which showed high level of autoantibodies also showed signifi cantly high level of RF, TNF-α, IL-1 and 6 and CRP. Conclusion: Th e results obtained so far suggests that IgG-methylglyoxal-glucose complex may have a role in the development of arthritis-like features in long term patients of diabetes mellitus. More biochemical parameters need to be analyzed in diabetic sera of immunized animals as well diabetes mellitus patients, including study of biochemical in joint fl uid of healthy and immunized rabbits.

Keynote Forum

Mohmmad Kamil

Zayed Complex for Herbal Research & Trad.Medicine, UAE

Keynote: Plants with special reference to flavanoids and their role in nutrition and obesity prevention
Human Metabolism 2019  International Conference Keynote Speaker Mohmmad Kamil photo
Biography:

Mohammad Kamil is a Fellow of Royal Society of Chemistry London, Head TCAM Research, Zayed Complex for Herbal Research and Traditional Medicine, Healthcare Licensing and Medical Education Division, Department of Health, Abu Dhabi, UAE. He was the recipient of Common Wealth Award-London, Convention Award of Chemical Society-India; Fellowship from Association of Common Wealth Universities-London, Global award on Unani Medicine. He has worked as Incharge of Drug laboratory, MoH India, Professor Jamia Hamdard University. He has more than 360 papers and abstracts in reputed journals and conferences.

Abstract:

The plant kingdom off ers a rich source of structural biodiversity in the form of a variety of natural products. As we know natural products continue to play an important role especially in and food and pharmaceutical industries. Besides medicament, plants have always been a common source of food and nutrition either as such or as dietary supplements. Th e unique nutrient richness of every whole, natural food can be show cased in a variety of ways. But there is no better way to highlight the unique nutrient richness of foods than to focus on their fl avonoid content. Flavonoid, one of the largest nutrient families known to scientists, covers a large group of naturally occurring, low molecular phenolic compounds found practically in all parts of the plant, include over 6,000 already-identifi ed family members. A large number of novel fl avonoids and bifl avonoids have been isolated from medicinal plants. Some of the best-known fl avonoids include quercetin, kaempferol, catechins and anthocyanidins. Obesity is the most prevalent nutritional disease and a growing public health problem worldwide. In this talk the anti-obesity potential of diverse plants such as Aloe vera, Camellia sinensis, Hibiscus sabdariff a, Hypericum perforatum, Phaseolus vulgaris, Capsicum annuum, Rosmarinus offi cinalis, Citrus limon, Punica granatum and some other common plants will be discussed. Researchers consider the potential of these plants as natural alternative treatments of some metabolic alterations associated with obesity. Market dietary supplements for obesity frequently contain undeclared/ hidden active ingredients that could be harmful to public health, the laboratory experience on this intensional adulteration shows that Plants play a untrivial role in public Health which is free from Adulteration contamination when compared with modern medicines. Hence plants with special reference to fl avonoids helps and prevents us from mutation especially in obesity prevention.